Medical Cannabis Studies

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Evidence for functional CB1 cannabinoid receptor expressed in the rat thyroid (2002)

This report aims to determine the functional expression of CB1 in the rat thyroid using a multi-method approach. The data shown in the results indicate that functional CB1 receptors that are able to modulate the release of T3 and T4 are manifested in the rat thyroid, and show a possible role of cannabinoids in the regulation of thyroid hormone activity of rat. View study
Exogenous hepatitis B virus envelope proteins induce endoplasmic reticulum stress: involvement of cannabinoid axis in liver cancer cells (2016)

In this study we investigated the activation of the ER stress pathway after the expression of ectopic hepatitis B virus (HBV) envelope proteins in liver cancer cells, and the role played by the B cannabinoid receptors. The results suggest that HBV envelope proteins can induce the ER stress pathway. The expression of cannabinoid receptors correlates directly with the ER stress function. View study
Experimental autoimmune encephalomyelitis disrupts endocannabinoid-mediated neuroprotection (2005)

Through experimental methods, these studies suggest the potential of cannabinoids in the development of neuroprotective drugs for the treatment of multiple sclerosis. View study
Expression and Functional Relevance of Cannabinoid Receptor 1 in Hodgkin Lymphoma (2013)

There is evidence that the CB1 cannabinoid receptor is expressed in certain types of malignant tumors. This study identifies the cannabinoid receptor CB1 as a characteristic of Hodgkin’s lymphoma, which could serve as a possible selective target for its treatment. View study
Expression of cannabinoid receptors type 1 and type 2 in non-Hodgkin lymphoma: Growth inhibition by receptor activation (2008)

These results suggest that therapies using cannabinoid receptor ligands will be effective in reducing the tumor burden in malignant lymphoma overexpressing CB1 and CB2 receptors. View study
Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations (1995)

In this investigation, the distribution patterns for the transcripts of both CB1 and CB2 in human immune cells and in various human tissues are reported, as analyzed by a highly sensitive and quantitative PCR-based method. The results found in this study show that CB1 and CB2 can be considered tissue selective antigens of the central nervous system and the immune system, respectively, and cannabinoids can exert specific actions mediated by the receptor in the immune system through the CB2 receptor. View study
Extract from Cannabis sativa -- Benefit Assessment According to �35a Social Code Book V [Internet] (2012)

Benefits of Cannabis sativa extract in the treatment of patients with spasticity due to multiple sclerosis. View study
Extraction of cannabinoids from cannabis sativa L plant and its potential antimicrobial activity (2012)

The present study aims to verify the use of Cannabis sativa L as an alternative medicine for the treatment of bacterial diseases. According to the result it could be determined that the extract of acetone, one of the cannabinoids extracted by aqueous extraction showed a greater antimicrobial activity by showing the zone of inhibition against the bacteria Pseudomonas aeruginosa, Vibro cholerae and fungi Cryptococcus neoforms, Candida albicans. View study
Gabapentin for Adults with Neuropathic Pain: A Review of the Clinical Evidence and Guidelines [Internet] (2014)

The purpose of this review is to investigate the clinical evidence on the efficacy and safety of the use of gabapentin in adults with neuropathic pain. In this investigation, it could be concluded that there is little evidence on the abuse and misuse of pregabalin, but existing data suggest that some populations with a history of substance abuse may be at increased risk of pregabalin abuse. View study
Gender differences in associations between pain-related anxiety and alcohol use among adults with chronic pain. (2019)

It has been shown that pain motivates the need and consumption of alcohol, and drinking to cope with pain predicts escalations in alcohol consumption over time. This research seeks to perform the first test of cross-sectional associations between anxiety related to pain, sex and alcohol consumption. View study
Growth inhibition and induction of apoptosis in colorectal tumor cells by cyclooxygenase inhibitors (2001)

In this investigation a study of the growth inhibition and the induction of apoptosis in colorectal tumor cells by inhibitors of cyclooxygenase is made. The data show that both COX-dependent cyclooxygenase-dependent mechanisms and COX-independent mechanisms are involved in the growth induced by non-steroidal anti-inflammatory drugs (NSAIDs) in colorectal tumor cells. View study
Gynecomastia and cannabis smoking A nonassociation among US Army soldiers (1977)

This study was conducted in a military population of American soldiers in Nuremberg Germany, where the incidence of marijuana use was almost 50%. Hypothesized the causal association between cannabis and gynecomastia based on the structural similarity of tetrahydrocannabinol (THC) and estradiol. View study