Cb1-Receptor Medical Cannabis Studies

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Allosteric Modulation of the Cannabinoid CB1 Receptor (2005)

We investigated the pharmacology of three new compounds, Org 27569, Org 27759, and Org 29647 in the CB1 cannabinoid receptor. In the equilibrium binding assays, the Org compounds significantly increased the binding of a CB1 receptor agonist, indicative of an allosteric effect of positive cooperation. The data presented demonstrate for the first time, that the cannabinoid receptor CB1 contains an allosteric binding site that can be recognized by synthetic small molecule ligands. View study
Cannabinoid CB1 receptor binding and acetylcholinesterase inhibitory activity of Sceletium tortuosum L. (2010)

In this study it was found that the unfermented alkaloid extract possesses a higher activity to bind to the CB1 receptor compared to the fermented one. The GC-MS analysis confirmed that the non-fermented alcoloid extract contains more alkaloids than the fermented one. View study
Cannabinoid receptor CB1-like and glutamic acid decarboxylase-like immunoreactivities in the brain of Xenopus laevis (2001)

In this investigation, the CB1 receptor distribution of cannabinoids was investigated in the brain of Xenopus laevis (anuran amphibians) by immunohistochemistry, using light and confocal laser scanning microscopy. It was demonstrated that the distribution of CB1 remains in the course of phylogeny. View study
Design, Synthesis, Biological Properties, and Molecular Modeling Investigations of Novel Tacrine Derivatives with a Combination of Acetylcholinesterase Inhibition and Cannabinoid CB1 Receptor Antagonism (2009)

Through this study it was possible to discover new hybrid molecules 12, 13, 20, 21 that exhibit inhibitory activities of AChE, as well as important antagonist properties of the CB1 receptor of cannabinoids. View study
Enhanced acetylcholine release in the hippocampus of cannabinoid (2001)

In this research, we studied whether the release of acetylcholine in the hippocampus and striatum and the release of noradrenaline in the hippocampus is altered in mice with CB1 receptor deficiency. It could be concluded in this study that the selective increase in acetylcholine release in CB1 7/7 mice may indicate that CB1 presynaptic receptors in cholinergic neurons of the mouse hippocampus are tonic activated and / or are constitutively active in vivo. View study
Evidence for functional CB1 cannabinoid receptor expressed in the rat thyroid (2002)

This report aims to determine the functional expression of CB1 in the rat thyroid using a multi-method approach. The data shown in the results indicate that functional CB1 receptors that are able to modulate the release of T3 and T4 are manifested in the rat thyroid, and show a possible role of cannabinoids in the regulation of thyroid hormone activity of rat. View study
Immunohistochemical analysis of cannabinoid receptor 1 expression in steatotic rat livers (2015)

In the present study, immunohistochemical analysis of the expression of the cannabinoid receptor 1 in steatotic rat livers was performed. It was observed that CB1 receptors are overexpressed in areas with steatosis, and show that CB1 in hepatocytes helps the formation of steatosis in rats. View study
Presynaptically Located CB1 Cannabinoid Receptors Regulate GABA Release from Axon Terminals of Specific Hippocampal Interneurons (1999)

There is clear evidence from the results obtained that cannabinoid-mediated modulation of hippocampal interneuron networks operates largely through presynaptic receptors in CCK immunoreactive basket cell terminals. The decrease in GABA release from these terminals is the probable way in which both endogenous and exogenous CB1 ligands interfere with hippocampal network oscillations and related cognitive functions. View study