Cb2-Receptor Medical Cannabis Studies

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Cannabinoid Type 2 Receptors Mediate a Cell Type Specific Plasticity in the Hippocampus (2016)

In this study we describe a mechanism of cell-specific plasticity in the hippocampus that provides evidence of the neuronal expression of cannabinoid type 2 receptors (CB2R) and emphasizes its importance in basic neuronal transmission. View study
CB2 cannabinoid receptors as an emerging target for demyelinating diseases: from neuroimmune interactions to cell replacement strategies (2008)

In this research, the study of current knowledge and the understanding of the usefulness of cannabinoids as therapeutic molecules for demyelinating diseases mediated by inflammation is carried out. View study
Direct suppression of autoreactive lymphocytes in the central nervous system via the CB2 receptor (2008)

It was verified that tetrahydrocannabinol (THC) produced by Cannabis Sativa and found in marijuana has been shown to be immunosuppressant in vivo and in vitro. This research focuses mainly on the function of the immune system and the regulation of effectors of T cells associated with autoimmune inflammation in the central nervous system (CNS). View study
Non-psychoactive CB2 cannabinoid agonists stimulate neural progenitor proliferation (2006)

Through this study it was possible to determine discoveries that provide a new physiological role for the CB2 cannabinoid receptor and show us a new therapeutic route to manipulate the fate of the neuronal progenitor cells View study
Role of CB2 receptors in social and aggressive behavior in male mice (2014)

This research was based on examining the role of the cannabinoid CB2r in social and aggressive behavior, using male CB1KO mice. View study
Targeting CB2 receptors and the endocannabinoid system for the treatment of pain (2015)

Cannabis contains the psychoactive component delta9-tetrahydrocannabinol (delta9-THC), and the non-psychoactive components cannabidiol (CBD), cannabinol and cannabigerol. In this review an analysis of the therapeutic possibility of CDB as a cerebroprotective agent will be made, highlighting the recent pharmacological advances, the new mechanisms and the therapeutic time window of the (CBD) in the ischemic stroke. View study
The CB2 cannabinoid receptor signals apoptosis via ceramide-dependent activation of the mitochondrial intrinsic pathway (2005)

9-Tetrahydrocannabinol and other cannabinoids exert pro-apoptotic actions on tumor cells through the cannabinoid receptor CB2.The results of this investigation show that CB2 receptor activation signals apoptosis via ceramide-dependent stimulation of the mitochondrial intrinsic pathway. View study
The serine hydrolases MAGL, ABHD6 and ABHD12 as guardians of 2-arachidonoylglycerol signalling through cannabinoid receptors (2011)

Lipid molecules not only serve as building blocks of the Central nervous system (CNS) but are being increasingly appreciated as physiological mediators of signal transduction.The endocannabinoid 2 arachidonoylglycerol (2-AG) is a lipid mediator involved in various physiological processes. In this study we reviewed recent research on monoacylglycerol lipase (MAGL), ABHD6 and ABHD12, three serine hydrolases that togetheraccount for approx. 99% of cerebral hydrolase activity 2-AG. View study
Treatment with CB2 Agonist JWH-133 Reduces Histological Features Associated with Erectile Dysfunction in Hypercholesterolemic Mice (2013)

Hypercholesterolemia is one of the most important risk factors for erectile dysfunction, mostly due to the impairment of oxidative stress and endothelial function in the penis. This research focused on the investigation of the effects of CB2 activation on oxidative stress and fibrosis in the corpus cavernosum of mice. View study