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View All (505)Endogenous Interleukin-1 Receptor Antagonist Mediates Anti-Inflammatory and Neuroprotective Actions of Cannabinoids in Neurons and Glia (2003)
The interleukin-1 receptor antagonist (IL-1ra) is an important anti-inflammatory cytokine that blocks all known actions of IL-1 and notably protects against experimentally induced ischemic, excitotoxic and traumatic brain injuries. This research was based on testing the hypothesis that the actions of CBs are mediated by endogenous IL-1ra. We report for the first time that both CB1 and CB2 receptors modulate the release of endogenous IL-1ra from primary cultured glial cells. View study