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• View All (505)Cannabidiol, a non-psychotropic component of cannabis, attenuates vomiting and nausea-like behaviour via indirect agonism of 5-HT1A somatodendritic autoreceptors in the dorsal raphe nucleus (2012)
This investigation was based on the evaluation of the hypothesis related to the activation of somatodendritic 5-HT1A autoreceptors in the dorsal raphe nucleus (DRN) produces the antiemetic / antinausea effects of cannabidiol (CBD), a primary non-psychoactive cannabinoid that is found in cannabis. The results of this investigation show that CBD produced its antiemetic effects against nausea through the indirect activation of somatodendritic 5-HT1A autoreceptors in the DRN. View study
Cannabidiolic acid prevents vomiting in Suncus murinus and nausea-induced behaviour in rats by enhancing 5-HT1A receptor activation (2012)
In this study, a comparison between CBDA and cannabidiol, CBDA showed a markedly higher potency to inhibit vomiting in animal models. As a result, CBDA has great potential in the treatment of nausea, vomiting and anticipatory nausea for which there is currently no therapy. View study
Interaction between non-psychotropic cannabinoids in marihuana: effect of cannabigerol (CBG) on the anti-nausea or anti-emetic effects of cannabidiol (CBD) in rats and shrews (2010)
This review was based on studying the potential of cannabigerol (CBG) to reverse the antiemetic and antiemetic effects of cannabidiol (CBD). Through the analysis of the results, it was concluded that the interactions between moderate doses of CBG and CBD can oppose each other in the 5-hydroxytryptamine 1A receptor (5-HT1A) in the regulation of nausea and vomiting. View study
Regulation of nausea and vomiting by cannabinoids (2010)
An important advance in the control of acute emesis in the treatment of chemotherapy was the finding that blocking a subtype of the 5-hydroxytryptamine (5-HT) receptor, the 5-HT3 receptor, could suppress the acute emetic response. Cannabis is taken as self-medication in patients with inflammatory bowel disease for symptomatic relief. The present investigation focused on the study of the regulation of nausea and vomiting by cannabinoids. View study
The effects of cannabidiol and tetrahydrocannabinol on motion-induced emesis in Suncus murinus (2012)
The results of this investigation show how compared to cannabidiol, cannabidiol acid (CBDA), shows a higher potency to prevent vomiting in shrews and nausea in rats and to improve the activation of the 5-HT1A receptor, View study
The Nonpsychoactive Cannabinoid Cannabidiol Inhibits 5-Hydroxytryptamine3A Receptor-Mediated Currents in Xenopus laevis Oocytes (2010)
This research focused on investigating the effect of the non-psychotropic cannabinoid derived from the plant, cannabidiol (CBD), on the function of 3A hydroxytryptamine (5-HT) receptors expressed in Xenopus laevis oocytes using pinching techniques. Two electrode voltage. View study