Medical Cannabis Studies

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Endocannabinoid binding to the cannabinoid receptors: what is known and what remains unknown (2010)

This review focuses on the binding of endocannabinoids to cannabinoid receptors. It is based on experimental and computational studies that have been used to demonstrate the nature of the interaction of endocannabinoids with cannabinoid receptors. View study
Endocannabinoid Signaling Regulates Sleep Stability (2016)

In this study we will show the results of a series of experiments in mice that measure sleep with polysomnography after several systemic pharmacological manipulations of the endocannabinoid system. The results support the hypothesis that endocannabinoid signaling through type 1 cannabinoids (CB1) is necessary for the stability of non-rapid eye movements (NREM), but is not necessary for sleep homeostasis. View study
Endocannabinoid signalling and the deteriorating brain (2015)

This research focused on endocannabinoid signaling and brain deterioration. After the approval of the first cannabinoid-based drug for the symptomatic treatment of multiple sclerosis, we investigated how endocannabinoid signaling (eCB) controls and is affected by normal aging and neuroinflammatory and neurodegenerative disorders. View study
Endocannabinoid System as Novel Therapeutic Target for Autism Treatment (2014)

The results of this study offer new perspectives in the investigation of autism. In addition, they indicate that the endocannabinoid system could be an important goal in the pharmacotherapy of autism. View study
Endocannabinoid System in First Trimester Placenta- Low FAAH and High CB1 Expression Characterize Spontaneous Miscarriage (2009)

Endocannabinoid levels are critical to regulate embryonic development and the window of implantation. Placental tissue represents a target for endocannabinoids, whose activity can regulate the outcome of pregnancy. View study
Endocannabinoids and energy homeostasis: An update (2014)

This article studies how the endocannabinoid tone, in addition to reinforcing the reward circuits and the modulation of food intake and health, controls the metabolism of lipids and glucose in several peripheral organs, particularly the liver and adipose tissue. This study gives a new focus on endocannabinoid control of the neurochemical causes and consequences of the imbalance of energy homeostasis, an approach that could lead to new potential treatments for obesity and related morbidities. View study
Endocannabinoids and fatty acid amides in cancer inflammation and related disorders (2000)

In this study the antitumor and antiinflammatory activity of the endocannabinoids anandamide and 2-araquidonoil glycerol is discussed; the amides of bioactive fatty acids palmitoylethanolamide and oleamide; and some derivatives such as N-acyl vanillyl amines. View study
Endocannabinoids and the haematological system (2007)

This research aims to review the interactions between cannabinoids and the hematological system. Endocannabinoids can regulate platelet function and possibly lead to thrombogenesis, and influence hematopoiesis. View study
Endocannabinoids as emerging suppressors of angiogenesis and tumor invasion (Review) (06/01/05)

The potential of cannabinoids to delay the growth and spread of cancerous tumors is extraordinary, as it highlights their safety profile in terms of toxicity and can also be used in the treatment of nausea and vomiting in patients with cancer. View study
Endocannabinoids as Guardians of Metastasis (2016)

This study summarizes the complexity of cannabinoid signaling in the area of tumor growth and metastasis. View study
Endocannabinoids in endocrine and related tumours (2008)

There is a wide range of pathophysiological conditions that are related to cannabinoids and recently it has been shown that endocannabinoids inhibit or delay cell growth, and the metastasis of tumors of the thyroid, breast and prostate. Which suggests its potential for in the treatment of various types of cancer. View study
Endocannabinoids in Liver Disease (2011)

The results of this study show that cannabidiol protects the mouse liver from acute alcohol-induced steatosis through multiple mechanisms that include the attenuation of oxidative stress mediated by alcohol. View study