Medical Cannabis Studies

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Endocannabinoids potently protect the newborn brain against AMPA-kainate receptor-mediated excitotoxic damage (2006)

The present research was based on the design to evaluate the neuroprotective effects of endogenous cannabinoid anandamide using a well-defined rodent model of excitotoxic brain lesions. This study provides experimental support for the role of endocannabinoids as a candidate therapy for excitotoxic perinatal brain lesions. View study
Endocannabinoids, feeding and suckling � from our perspective (2006)

In the summary of this journal some aspects related to the effects of the endocannabinoid system on feeding, appetite, suction and lactation are mentioned. It was found that anandamide, an important endocannabinoid, increases appetite in mice View study
Endogenous cannabinoid system as a modulator of food intake (2003)

Scientific studies have pointed out the therapeutic potentials of cannabinoid compounds and have highlighted their ability to stimulate appetite. The objective of this research is to provide general information on how the endogenous cannabinoid system acts as a modulator of food intake, obtained from studies in humans and animals View study
Endogenous Interleukin-1 Receptor Antagonist Mediates Anti-Inflammatory and Neuroprotective Actions of Cannabinoids in Neurons and Glia (2003)

The interleukin-1 receptor antagonist (IL-1ra) is an important anti-inflammatory cytokine that blocks all known actions of IL-1 and notably protects against experimentally induced ischemic, excitotoxic and traumatic brain injuries. This research was based on testing the hypothesis that the actions of CBs are mediated by endogenous IL-1ra. We report for the first time that both CB1 and CB2 receptors modulate the release of endogenous IL-1ra from primary cultured glial cells. View study
Endothelium-dependent metabolism by endocannabinoid hydrolases and cyclooxygenases limits vasorelaxation to anandamide and 2-arachidonoylglycerol (2007)

These findings suggest that the local activity of fatty acid amide hydrolase (FAAH), monoacylglycerol lipase (MGL) and cyclooxygenase (COX), which is present to a large extent in the endothelium, limits the vasodilator action of endocannabinoids in the arteries small mesenteric rat. Despite the differential roles that these enzymes make in relaxation to anandamide versus 2-AG, the results indicate that the inhibitors of these enzymes increase the vascular impact of the endocannabinoids. View study
Enhanced acetylcholine release in the hippocampus of cannabinoid (2001)

In this research, we studied whether the release of acetylcholine in the hippocampus and striatum and the release of noradrenaline in the hippocampus is altered in mice with CB1 receptor deficiency. It could be concluded in this study that the selective increase in acetylcholine release in CB1 7/7 mice may indicate that CB1 presynaptic receptors in cholinergic neurons of the mouse hippocampus are tonic activated and / or are constitutively active in vivo. View study
Enhancing the Activity of Cannabidiol and Other Cannabinoids In Vitro Through Modifications to Drug Combinations and Treatment Schedules (2013)

It is proven that cannabinoids have numerous therapeutic qualities. In this study the activity of six cannabinoids, used alone and in combination in leukemic cells, was analyzed. View study
Epidiolex (Cannabidiol) in Treatment Resistant Epilepsy (2015)

This study has obtained promising results for Epidiolex (cannabidiol) as a drug for treatment in children with a variety of epilepsy syndromes. It was found that children and young adults with Dravet’s syndrome had the greatest reduction in seizures. More randomized controlled trials are being conducted to support these results. View study
Essential oils of different cultivars of Cannabis sativa L. and their antimicrobial activity (2001)

This study aims to determine the antimicrobial activity of different oils derived from five different cultivars of Cannabis sativa. View study
Estrogenic induction of cannabinoid CB1 receptor in human colon cancer cell lines (2008)

Cannabinoids have the ability to activate cannabinoid receptors CB1 and CB2. It is possible to control the proliferation of colon cancer by an additional mechanism of regulation by increasing the expression of CB1 by 17b-estradiol. View study
Evaluation of Serum Cytokines Levels and the Role of Cannabidiol Treatment in Animal Model of Asthma (2015)

There is a great possibility that CBD can be used as a pharmacological treatment for asthma, because it can modulate the inflammatory responses of the disease…. View study
Evaluation of the Cyclooxygenase Inhibiting Effects of Six Major Cannabinoids Isolated from Cannabis sativa (2011)

This study shows that canbinoids can help reduce the production of prostaglandins that are important mediators in the inflammatory process. In other words, the anti-inflammatory potential of cannabinoids is demonstrated. View study